Great book...important information. Had already read the book, but purchased it to have in my library as a reference.

This book is the secret to all heart, stroke, and diabetic problems. Dr. Ignarro findings is a modern day miracle. The whole world needs to know about his findings!!!!!!

This is an excellent book. Easy to read and understand for the lay person. The scientific medical evidence is available in another book by the author.

This book and Dr. Ignarro's recommended NO boosting regimen is incredible. It lowered my blood pressure to a healthy level in just 10 days with no side effects.

http://www.DrIgnarro.com is a great source of information to learn more about Ignarro, his work, and Nitric Oxide.

Everyone should say YES to this book....not only is it quick reading, it makes sense, and both of us (my husband and I)have improved blood pressure, cloesterol, joint pain, energy --- you name it we feel GREAT!!!!!

Excellant work on Nitric Oxide - his 30 years of research has paid off for all of us. I don't agree with his views of some things like eggs and soy, however, in the areas of his expertise it is a great work!

Information is this book echo's many other books. The information is probably mostly true. Whatever, anyone following this advice has a better chance to live a long life.

The book is written in such easy, conversational style, that you almost think Scientists could be human after all. The topic of heart health is given enormous hope and I have already started implementing the program recommended by Dr Ignarro and have noticed a considerable drop in my blood pressure in just two weeks.

Well written easy to read.Very promising health benefits. Finding and keeping up with a number of supplement purchases and cost in Australia is somewhat difficult.

I started using Arginine as a body building supplement (NO2 from GNC) before I reasearched the health benefits. Agrinine, taken properly, can improve blood flow thoughout the body and boost the body's regenerative abilities by making nitric oxide (a gas) available to the body. In my case, my asthma symptoms improved drastically and my feeling of well-being and energy increased dramatically. I decided to research Arginine to find out why it made me feel so good. This book, by Louis Ignarro, one of the Nobel Prize winning doctors who discovered nitric oxide's role in the body, lays out a plan involving Arginine plus several other supplements and healthy living. In the book he explains how nitric oxide works. Like many other books about nutritional supplementation, this book is pushing a product marketed by Dr. Ignarro. I don't use Dr. Ignarro's product, but found the information in the book very useful and informative.

Great Book. Well written and lot's of specifics on steps you can take to improve your health. Easy to read and understand. Recommend it to anyone.

After so many pharmacutical companies issues bad drugs, FDA pulling drugs off the market. Dr Ignarro's book hits it dead on, heart disease is reversable. Dr Ignarro's product Nite works he sells through Herbalife is worth every penny.

Bought the book after seeing it presented on Dr. Phil's show. Dr. Ignarro writes in an easy to understand way. I am currently using BSN's NO-XPLODE & Nitrix plus the anti-oxidants mentioned in the formula, and working out with weights. I've lost 27 pounds and all of my bloodwork results have started improving. I weighed 300 lbs, have high blood pressure and diabetes. I go back for more bloodwork in 2 months. Thus far, I'm pleased with Dr. Ignarro's recommendations and have bought 7 more "Used/New" copies of the book from Amazon, to give to family and friends.

The info in this book is by far the most important that you can read. I have a family history of heart disease. This is the biggest reason for my reading this book. To learn the what,where and how this little know natural forming chemical substance last and works was amazing. This knowledge and it's practical application will vastly improve your health, as it has done mine. I am feeling better, doing more and at a eaiser and faster paste. My cholesterol in lower as is my blood pressure. I feel great and exercise regularly. Try the plan in this book and it will work for you as it did for me. Remember, it is us who fail not the plan or program or system.

Dr.Ignarro has written a most informative book in the easy read style. I read it in 2 days. I have already begun his suggested treatment. Nothing but feel good effects from supplementation he suggests.

I first read about NO in a book by Durk Pearson and Sandy Shaw called "Life Extension". Durk is a research scientist, MIT graduate, and Sandy Shaw is his girlfriend or maybe by now wife. She is also a scientist. They were , in my opinion, responsible for all the talk about antioxidants and their affect on destroying free radicals. In their book they speak about NO and of the many benifits it can have on your health. In order for it to be effective you need to take it at night before going to bed, as the NO is produced during sleep. You also need to take it on an empty stomach . The body tends to use nutrients in a rather competitive way in that they will tend to compete to see which one gets to the brain first. This doesn't apply to other supplements, as most like vitamins work best with food This is a simple way of putting it, but maybe you get the idea. By taking it on an empty stomach it can do what it is intended to do without interference. You can take L-Arginine alone or together with L-Ornithine. As stated before, in another review, you need to take at least 6 grams of L-Arginine or a combination of L-Arginine and L-Ornithine at a two to one ratio, 4 grams L-Arginine and 2 grams of L-ornithine, for example. You can purchase both at any good health food store. Some have it in two pound canisters, such as NOW NUTRITION for , depending where you you buy it and how much , around $25.00 to $30.00 for two pounds of the L-Arginine. L-Ornithine is more expensive, and I have found it to be proportional to the ratio I mentioned above, at about twice the price for an equal amount, but twice as effective also. Durk Pearson and Sandy Shaw use it as a precursor to Human Growth Hormone. The combination also causes to body to release more HGH while we sleep. As we age less and less HGH is produced, and the L-Arginine and the L-Ornithine, if you choose to use both or the L-Arginine alone cause the body to release more of what we have. This results in anti-aging, more muscle, less fat, smoother skin, normal blood pressure, and the list goes on and on. I don't tell you to take this, I only tell you what the research scientist are reporting. At the price mentioned above, this is far less than HERBALIFE at around $80-$90 for less than a pound, and it is ALL YOU NEED ! If you take other supplements do so at another time during the day, and not at night when you take the L-Arginine and L-Ornithine, it will only interfere with it's ability to be assimilated and utilized. The Book Life Extension is probably still available, and at 800 pages or so is filled with information about how the authors test all their findings on themselves. I hope this helps anyone reading it to decide for themselves. Good Health To All.

I read this book, and it was interesting. I even tried a supplement called Cadio Discovery, developed by Dr. Murad, who worked with Ignarro on heart research. Cadio Discovery was sold at Wal Mart but I noticed that they are discontinuing the sales of the product, and the www.cardiodiscovery.com site seems to be permanently disabled. There are reports that L Arginine could be dangerous. In a recent study, men with a history of heart trouble were given L Arginine supplements, and a like group of men were given a placebo. 6 of the men that were given L Arginine died during the study. None of the placebo group died. Please do your research before taking any of these products.

Dr. Ignarro won a Nobel Prize for his work and this is a breakthrough report on the research and how YOU can help yourself feel better and healthier. My only complaint is that the book is not quite forthcoming about the purchaseing source for the Niteworks product that contains all the ingredients to boost your power. I thought I could find it in nutrition stores or better pharmacies. Apparently only Herbalife carries the product and it is very expensive - around $90 a month. I have tried to get the amino acids from other places, but one ingredient has been impossible for me to find.
The book has largely been ignored by the medical community and as a Health care professional, I wonder why. I only know that I am a skeptic and was wholely surprised by the increase in my energy levels within 10 days. I plan to put my elderly parents on the program ASAP. I've been on the program for about 3 weeks and feel 5 times the energy I had before. (I have even started exercising again) I will stay on the program as long as I can afford the Niteworks.

This book is easy to read, interesting, and full of potentially life-saving information. By the time I had read enough to learn how to improve my heart health, and followed Dr. Ignarro's recommendations, I lowered my blood pressure from 140/88 to a very low 90/57! Later readings were more in the normal range of 120/70...this after 30 years of hypertension! The only real changes I made were in diet, and adding a couple of amino acids that were the basis of the dramatic drop in blood pressure. I am recommending this book to my friends and loved ones with heart disease.

I happened to pick this up in Borders one day...having a scientific background i remember the 1998 Nobel Prize and NO(nitric oxide). NO activates the production of cyclic GMP, a critical messenger in human cells and responsible for vascular relaxation and other stimulatory events...including the well known Viagra response. NO is a gas which easily diffuses through the human body and acts as a hormone. Indeed NO may be the most relevant discovery in medicine along with aspirin and penicillin.

Dr Ignarro is brilliant...i believe he wrote this book so that the average Joe could improve his heart and sexual health and he recommends taking the naturally occuring nutrients arginine and citrulline to increase NO levels. Unfortunately the average Joe with early heart disease responds to all the TV ads and will take Viagra as prescribed by his doctor. Ignarro's recommendations are much safer and effective for long term improvement of heart disease and high blood pressure problems. Sadly most doctors will not know this.

I have not tried the ideas listed in this book yet - but I plan to. I find it difficult to synthesize the viewpoints of so many experts in the field of nutrition and come up with a truly valuable plan for living. The author, Dr. Ignarro, is a bit repetative but very clear in his ideas. He writes in an organized format and is easy to understand. The fact that he is a Nobel Prize winner gives a great deal of credence to his solutions. I would recommend this book to anyone who is concerned with their health. We must listen to those who speak with wisdom instead of jumping on the bandwagon of the next craze. Why not 5 stars? I always hold one star out for sceptical consideration - After all, cold fusion never materialized.

Ignarro's book is the first (and I've read plenty) that has convinced me that proactive prevention of heart disease is possible! The old standbys of lowering your cholesterol, exercise and healthy eating are included, but there is so much more in his book. He recommends specific supplements to take and clearly explains how they work together and why they are important for a healthy heart. The supplements are inexpensive, have no side effects, and are kept to a minimum. His nobel prize speaks volumes but this volume is easy to read and understand. I'm reordering more of his book for family and friends!

It's a quick read,.....larger print than than usual, the layout is an easy and comfortable format, and the chapters progress in a manner that's pleasant to read....not too technical. The information contained about NO is fascinating,....I've learned so much more about how the body functions, and am definitely considering purchasing the recommended nutraceuticals.....not just another "how to" book, though, at times, it reads that way.....helps that the author has won the Nobel Prize....

Aside from exercise and proper diet we should all try to keep ourselves informed on things that can help our bodies. I believe this to be a sound book written by a author who has not only researched and published on this topic but also won a pulitzer for it!

Great great great book. Well written and a must read for
all who have heart issues and even those who do not.
I have purchased more than one and sent to family and
friends. jane davis

Nitric Oxide keeps arteries and veins free of the plaque that causes stroke. Healthy NO levels necessitate the following nutritional supplements: L-arginine 4-6 grams, L-citruline 200-1000 mg, Vitamin C 500 mg, Vitamin E 200 iu, Folic Acid B9 400-800 mg, and Alpha lipoic acid 10mg. L-arginine enhances blood flow because it is converted into NO in the body. L-citrulline is converted into L-arginine which in turn increases the production of NO. L-citrulline is necessary for the increased production of L-arginine.

Nerve cells in the brain and lungs produce NO. The white blood cells produce NO in such large quantities that the NO can help overpower attacking microorganisms.

Doses of L-arginine less than 4-6 grams will produce 0% increase in NO. NO activates enzymes that produce cyclic guanosine monophosphate (GMP), a 100 fold. GMP is the agent that causes the smooth muscle walls of the Endothelium cells, of the blood vessel, too relax and widen. The result is an increased flow of blood and oxygen to the heart and a decline in blood pressure readings. There are two blood pressure readings too monitor: systolic pressure, the force on your arterial wall as the heart contracts and diastolic, the pressure on the wall when your heart relaxes. 50 million Americans have high blood pressure, 32% have hypertension and 26% are taking high blood pressure medicine. If the arteries are relaxed and widen then blood flows more easily and blood pressure decreases. The optimal condition is when your vessels around your heart are flexible with a diameter of about 3 millimeters. Danger occurs when atherosclerosis starts to form. Atherosclerosis is a process of plaque accumulation that leads to the hardening of the arteries. Healthy endothelial cells are slick like Teflon. Fatty buildup is composed of low density lipoproteins (LDL 10 million patients are taking LDL cholestrol lower medicine), waste products of the cells, calicium (nanobacteria deposits), and fibrin. Once plaque becomes brittle, the plaque can crack and rapture and dislodge from the arterial walls. The body responds to this rupture by causing a blood clot to form. The result is blood blockage and heart attack. When the endothelial cell is damaged, the body releases monocytes and leukocytes that release chemicals called inflammatory mediators that trigger inflammation (Periconne thesis).

Dr. Louis J. Ignarro, a Nobel Laureate in Medicine, has compiled the history of a discovery that continues to be proven to "Prevent-Even Reverse-Heart Disease and Strokes" and specifically describes "A Proven Program for Boosting Production of the Body's Own Wonder Drug" in "NO MORE HEART DISEASE", St. Martin's Press 2005, 248 pages.
Dr. Ignarro's preliminary research explained that there was a naturally occurring substance that C-Laureate Dr. Robert Furchgott called "endothelium-derived relaxing factor" (EDRF). Dr "I" identified Nitric Oxide (NO) between 1978 and by 1986 proved that "nitric oxide's role in the body was definitely a signal molecule, which performed crucial cardiovascular functions." Arterial plaque he illustrated, "if you think of the living healthy wall cells as being slick like Teflon, while an unhealthy cell is sticky like Velcro, causing plaque to attach" then you've got his idea. His program titled, "Say Yes to NO" recognizes that "red meat fish, olive oil, nuts and pomegranate juice enhance the body's ability to produce NO. Unfortunately he cautions, you would have to eat one hefty steak all three meals a day to maintain a beneficial level of NO. Therefore he recommends a NO boosting blend of amino acid supplements: L-Arginine, L-Citrulline plus Alpha Lipoic Acid, C, E, and Folic Acid and adds, "the acceleration of blood that occurs during exercise can stimulate the production of the enzyme NO synthase, which is important to the body's production of NO." That means it works better if you exercise!
Although this 2005 book publicizes NO's effect it doesn't include John P. Cooke MD Ph.D, the head of Stanford's Medical Research team as the first to include L'Arginine in a candy bar to tempt the American public to get NO every day and only mentions co-Laureate Ferid Murad, the Houston pharmacologist who conducted the earliest studies on nitric oxide.
Some will try to get enough L-arginine and L-Citrulline from foods but the short list only includes: almonds, dark chocolate, garbanzo beans, melons, peanuts, red meat, salmon, soy and walnuts. The good news for choco-holics, a prodigious Penn State U study concluded, "that the cocoa/dark chocolate diet interfered with the oxidation of LDL cholesterol." So, Dr. I suggests consuming in moderation - "divide it in small pieces and eat them throughout the afternoon and evening, one bite at a time." Therefore, next time you're asked to go for coffee, choose cocoa (hot chocolate) because the poly phenols Harvard Med School and Brigham Woman's Hospital showed that the "antioxidants in cocoa support NO synthesis." Or, drink a glass or two of red wine because it's rich in polyphenols that "markedly stimulate NO production." Purple grape or pomegranate juice may even be better than wine, and don't forget to eat some blueberries because they contain pectin, which is best known for its cholesterol lowering fiber.
To get all the best results, when should you boost your body's production of NO?
"Once a day before bedtime or twice a day - in the morning and before bedtime," and when combined with a minimum dose of 200 mg L-Citrulline, "a synergistic effect occurs," Dr. I prescribes. For those who may be concerned, he assures "no side effects have been reported in the medical literature."
The most important news Dr. I has for a diabetic is that NO can, "halt the development and progression of diabetic complications . . . reduce the risk of diabetic retinopathy. NO can make a difference in your quality of life." The same is true for Cancer - NO can inhibit the growth of cancer cells."
Sensible people with any of these maladies would be well advised to go online to discover that Argenix in an easy to take liquid with both arginine and citrulline. Or wait until a white coat Doctor does a double blind study.
� 2006 Dan Kassell
All Rights Reserved

I like it so much, i'm almost done with my third reading. at some point i may be able to recite the ten chapters word for word (being facetious).
During the last week of February, i ordered No More Heart Disease. the next week in March, i had a mini-stroke. the 2nd week being admitted at a rehab center, the book arrived. i was discharged after 4 weeks and finished reading this book. reading No More Heart Disease really gives me positive incentives to work the rehabilitation program schedules. the medical staff at the rehab are pleased with my recovery.

This book was very informative. I talked in depth with my cardiologist about Nitric Oxide and he agreed to allow me to start the supplement program. After only 3 days on the supplements and for the first time in years, the arthritis in my hands left me alone. Thanks to this book, I have added more foods, that help your body create more NO, to my diet. I feel that this book will help me live a longer and healthier life.
All my thanks to Dr. Ignarro.

I think this is a great book and would recommend it without hesitation. Nitric Oxide is a really interesting subject and this book helps to explain it really well. The only reason I did not give it 5 stars is because Dr Ignarro understanding of cholesterol is rather traditional, and maybe he should familiarise himself with the research undertaken by Dr Uffe Ravnskov [...] The French for example eat lots of cholesterol and saturated fats, and their heart attack rates are very low by comparison to the USA. However I accept that Dr Ignarro is not trained in cholesterol and so don't want to be unkind. Putting cholesterol aside, this is a really great book and worth your time and money. It does come across as a bit `salesy' which is not what you would expect from someone who has won a Nobel Prize, and this may be off-putting to some readers who take offence if something is too commercial. I suspect some marketing or PR person got involved somewhere along the way with this book and felt it needed hyping up. But it's an easy read, and you won't fall asleep, which is more than I can say for some books. Nitric Oxide is an important discovery, and Ignarro and his colleagues deserve lots of praise for bringing it to our attention.

It appears that everything in the book does have substantial basis, however, no where does he mention that by taking his recommendations a person risks the possibility of getting an enlarged heart. John Hopkins have done studies this past May which indicate an enlarged heart is a real possibility. So please be sure to always find out the "bad" along with the "good" which doctors tout even if it means going to other resources to research additional information.

A laborious advertisement for a nutititional supplement. Sad because Nitric Oxide is a valuable piece of information in its own right.

NO More Heart Disease may very well be THE MOST IMPORTANT BOOK YOU WILL EVER READ.

If you or someone you care about has

1) high blood pressure
2) high cholesterol
3) history of blood clots
4) angina.....

You / they MUST read "NO More Heat Disease" - NOW!

The author was awarded the NOBEL PRIZE for his discoveries about the roles that Nitric Oxide play in both preventing & even reversing existing heart disease (its primary benefit), as well as cancer, diabetes and maybe even neurodegenerative disorders such as Alzheimer's disease.

To make it short & simple: healthy levels of Nitric Oxide may well be the MOST IMPORTANT FACTOR for reducing your risks of suffering a heart attack and stroke - 2 of the 3 leading causes of death and long-term disability in America, as well as cancer, diabetes-related complications and Alzheimer's disease.

All of this can be easily accomplished with simple dietary changes, MODERATE (not heavy, strenuous) exercise and a precise combination of safe & highly effective nutritional supplements.

You DO NOT need any DRUGS or INVASIVE surgical procedures to reverse plaque buildup in your arteries / veins / capillaries!

If you or someone you love is scheduled to undergo bypass
surgery, angioplasty or carotid endarterectomy - have them read this book first - it will save them a tremendous amount of physical & emotional pain and suffering!

This book may very well change the way heart disease is treated.

Heart surgeons and the pharmaceutical industry will stand to lose a fortune in profits thanks to "NO More Heart Disease"...so don't be at all surprised if you hear doctors & drug companies attack the legitimacy of the book's non-drug / non-surgical approach to preventing & reversing heart disease.

God bless Dr. Louis Ignarro.

His NOBEL PRIZE-WINNING work will save countless lives - maybe yours or that of someone you love!

I've had blood pressure problems and high cholesterol for the past several years and have been on a number of drugs, with various levels of side effects. My doctor never spoke to me about nitric oxide and the role it plays in my disease - so I was completely taken aback when I read NO More Heart Disease, and learned that the research behind this discovery had won a nobel prize -- and I had never heard of it. Every person who has heart disease or at risk should understand the action of NO in the disease. This book provides guidance on a common-sense program for improving heart health without drugs. Reading NO More Heart Disease has been an eye-opener for me - I did not how recently the importance of NO in heart health has become understood. I am excited about giving Dr. Ignarro's program a try.

I really enjoyed reading NO More Heart Disease. Dr. Ignarro's story is an interesting one and his message regarding heart health is very convincing. I always thought that breast cancer was the biggest health issue for women, but now I understand that heart disease is a much bigger concern. I am already fairly active, but Dr. Ignarro's step by step program of foods and nutrients is easy enough that I am going to integrate it into my familys' daily routine.