This book contains so much interesting information about the recreational drug MDMA (ecstasy). It is very easy to read and many sections are in interview format. There are sections that are heavy on the chemical and neurotoxicity of the drug, but the author does a great job making it comprehensible to the average layman like myself. I believe this is a very unbiased look at the benefits of this drug and its clinical psychiatric use. It may be the prozac for the new millenia!

 One should start by putting things in perspective. The following background is necessary not only for all studies of psychoactive drugs, but for all studies of human behavior.
 There were about 400,000 USA deaths due to tobacco, 100,000 each to alcohol and prescription drugs and about 7600 to aspirin and other OTC painkillers. Worldwide we can expect that the figures will be about 10 million for tobacco, 2.5 million each for others and about 200,000 for aspirin and OTC painkillers. There may be 1 million people in the world with fetal alcohol syndrome(severe brain damage due to maternal drinking) and it is the leading cause of mental retardation in most countries.  There are also at least 15 million people who have fetal alcohol effect(lesser degrees of brain damage) with about 200,000 born every year. I suspect this is a gross underestimate.

 None of the psychedelics nor cannabis are known to produce fetal injury when taken in normal amounts.  All things considered, if you calculated the lifetime risks of death or injury from taking ecstasy, it is probably comparable to that of driving ten km and significantly less than that of putting on a pair of skis.

In addition, the young people who comprise the vast majority of the users are heavy risk takers, a very percentage of whom have personality disorders.  There are about 60 million schizophrenics and the same number of manic depressives in the world.  When you add the depressives, schizotypal disorders, anorexics, alcoholics etc it is clear that perhaps a billion people have major mental problems, nearly half of all those are in the prime drug taking ages. In addition nearly all of us have periodic mood swings, medical problems and personal crises. 

 Based on various data in this book and elsewhere,  it appears that about 20 million people will take something like 200 million pills of ecstasy each  year.  In 1998 there were about 9 deaths POSSIBLY connected with ecstasy in the USA. These seem to actually be due to drinking too much or too little water and likely to taking large amounts of other drugs or alcohol.    Ecstasy deaths(like those for marijuana and other psychedelics) are extremely rare and seldom if ever due to the direct toxicity--the psychedelics having some the widest margins between the effective and the toxic doses of any drugs in medicine. 

 The fact is there was enough data to prove the psychedelics were safe and therapeutically effective 25 years ago.  If they were available OTC or perhaps even on prescription with the same general indications as say, antibiotics, the black market and adulterated drugs would quickly fade away.

 It is not clear that anyone has ever had serious permanent mental problems due to taking ecstasy(though they often have serious permanent benefits) and its potential as a therapeutic agent are enormous. It has a long and remarkable history as a highly effective and safe therapeutic adjunct.  Nevertheless, as with many other psychedelic drugs, the federal government has chosen to ignore medical advice and legal opinion and classify it with heroin as a Schedule 1 drug with no recognized medical value and the governments of many other countries have followed along like trained dogs. 
This book aims to provide accurate information on all aspects of MDMA(ecstasy) and it accomplishes this quite well. 

 The authors mostly try very hard to be fair and balanced in their approaches and are mostly experts in the field.  They caution about the difficulty of applying the data on animals to humans but they often do not go far enough in emphasizing the probable irrelevance of the animal data to humans.  E.G., in the chapter on risks, not only do most of the animals get large amounts intravenously, but there are no good control data.  We need to see what happens with the same animals with the same routes and relative doses with a variety of commonly used medicines(eg, antidepressants, mood elevators, asthmatics, appetite depressants, cold medicines, OTC pain pills etc etc. Will they, as one suspects, show similar changes in their brain chemistry, memory, blood flow etc?  Nobody knows as the government sponsored studies almost never test them.  We can only guess from scattered data in other studies which often show the same kinds of changes.  Consequently, if we applied the same criteria used for Prozac, Elavil, aspirin etc  we would either have to outlaw nearly all the drugs in current medical use or legalize all the psychedelics. However the government has no interest in being rational, fair or even sane and certainly none in allowing us the freedoms supposedly guaranteed by the Consititution, and the Bill of Rights. 

 Wantly badly to err on the side of caution, several of the authors repeatedly warn(eg, p111) of the possibility of subtle long term damage yet they seem unconcerned by some half century of massive long term use of antidepressants, amphetamines, etc to say nothing of alcohol, caffeine and nicotine.  And only one bothers to mention(p 139) that a half century of studies on chronic users(often intravenous and multidrug abusers) of the closely related amphetamine and methamphetamine have failed to show evidence of Parkinsonism. And let us keep in mind that about 99% of all the MDMA fans use it only a few times in their lives in low oral doses.  The same is true of most other psychedelics and so it seems likely that the only long term behavioural effects in the vast majority of users will be some increase in insight, less rigid personalities, broader interests in art, music, religion and a generally happier life.

 The young people who comprise the vast majority of the users are heavy risk takers, a very high percentage of whom have personality disorders.  There are about 60 million schizophrenics and the same number of manic depressives in the world.  When you add the depressives, schizotypal disorders, anorexics, alcholics etc it is clear that perhaps a billion people have major mental problems - nearly half of all those are in the prime drug taking ages. In addition nearly all of us have periodic mood swings, medical problems and personal crises.  In addition as some of the authors note (and as Holland often interjects in her editoral notes) the ecstasy users are usually taking other drugs before, during and after their ecstasy(and marijuana and other psychedelic experiences).    These include, almost universally, alcohol, tobacco and caffeine(which are almost always ignored) as well as cocaine, amphetamine and methamphetamine, ketamine, dextromethorphan, asthmatics, and a wide variety or uppers, downers and prescription mood altering agents including birth control pills and Viagra, to say nothing of the steroids now approaching universal use in professional athletes in all sports(no the new ones cannot generally be detected).  Yet as Holland and others note, these other drugs are usually not mentioned and a really good drug screen on the users appearing in clinics or used in studies is seldom done.  The point of all this is that the claim that ecstasy is dangerous is not correct(and other psychedelics are mostly the same).  It's probable that skiing kills and injures more people in one season(most in car accidents!) or tobacco or alcohol in one day, than all psychedelics combined have done since the beginning of recorded history.  Thus the demonizing of them does not correspond with reality.  In fact since more than 99% of all media on MDMA is negative it would be reasonable and desireable to remove all the comments on possible negative effects from this book and publish it as MDMA: miracle medicine for the 21st century! 

 Billions of dollars have been spent on studies ánd programs aimed at showing that psychedelics are bad and almost nothing on their many positive effects. In fact most of the world has(naturally) followed the poorly educated, deeply repressed, conservative Christians who control the US Govt. in outlawing, for over 30 years, any medical use and any research that might show benefits!  The vast amount of practical experience with their benefits cannot even be published and the tens(maybe hundreds) of millions who have had major positive experiences cannot talk about them.  Its clear as day that the only serious problem with ecstasy is that it is new and it triggers the control and maybe the contamination templates in the monkey mind. 

 The evidence presented here shows that MDMA is very safe, rarely illusionogenic(though most authors follow the common practice of calling visual effects hallucinations, which they defintely are not).  Hallucinations-eg, seeing and hearing persons who are not there- are characteristic of schizophrenia, toxic psychoses, belladonoids(eg datura), and dissociative anesthethics(PCP, ketamine).  They are so rare with psychedelics that one suspects that nearly all such cases are due to preexisting psychosis.  MDMA probably belongs(with a variety of other drugs invented by Shulgin) in a new class called entactogens.  These are unique in that in addition to catalyzing positive emotions and bonding, they are rapidly acting, nonsedating anxiolytics(decrease anxiety), anaesthetics(pain killers) and antidepressants(which take days or weeks to act in comparison with minutes for MDMA!) with remarkably few and mild side effects(in dramatic contrast with nearly all medical drugs which have severe side effects that are often fatal).

 There is along chapter devoted to the toxicity data on rats and monkeys usually dosed intravenously and chronically with huge amounts and to reports on chronic, high dose often IV multiple drug abusers, probably with a high incidence of preexisting mental adn physical problems.  Only Holland's desire for completeness justifies the inclusion of such data in this book.  It has about as much relevance to the occasional oral use by the vast majority of MDMA users as the study of chronic alcoholics has to the description of a dinner party where 2 people consume a bottle of wine. 

 Jansen(p 87,89) is afraid of this self medication at home and expecially at raves(massive all night music events)without a therapist but probably over 100 million people in the last 40 years have taken some 2 billion trips with LSD, MDMA, MDA, mescaline, peyote, amanita, psilocybin mushrooms, ketamine and many other psychedelics with amazingly little evidence of negative effects. And of course, syrian rue, amanita muscaria, peyote and other cacti, pitruri, datura, ayahuasca and countless other plants have been consumed in hundreds of societies for thousands and likely for tens of thousands of years, giving rise to much of our art, music and religion, with hardly a trace of tradition regarding bad effects, which people were usually quick to notice and avoid.  And, as Jansen(the author of an excellent recent book on ketamine)notes, nobody writes up, or sends to the media, reports of positive effects. 

 One way to look at the really big picture is to call on our modern knowledge of cognitive and evolutionary psychology which tells us that the foundations of human behavior are the result of the mechanical, unconscious functioning of the inference engines or templates that were evolved hundreds of thousands of years ago(or millions or tens or hundreds of millions depending on one's point of view) to enable small bands of primates to survive long enough to reproduce.  These templates take in all the info from the eyes, ears, etc. and memory and produce feelings or intuitions about how one should behave to optimize survival.  However templates for control, predator avoidance, contamination, etc which were so rational in a small group on the African savanna(or in the trees a few million years earlier) are totally irrational and and even suicidal now.  Relentlessly, and in agonizing slow motion, 6 billion people are following the dictates of their templates while the biosphere and what passes for civilization collapses around them. The devious, power mad, repressed and unconscious persons who gravitate to positions of power in government, military, religion, industry and academia are orchestrating the end of the world while their like-minded constituents cheer wildly.  It is these people and not the psychedelic users who are the criminals.

 Ecstasy and other psychedelics, preferably combined with various kinds of meditation and other physical and mental therapies have a major potential to help people to break free from the automatisms that have guided behavior for millions of years. Billions of people need this medicine to avoid a lifetime of suffering and unhappiness and often, suicide.  Let us hope that it holds the answer as there does not seem to be any other and let us hurry--time is running out. 

�One�should start by�putting things in perspective. The following background is necessary not only for all studies of psychoactive drugs, but for all studies of human behavior.
�There were about 400,000 USA deaths due to tobacco, 100,000 each to alcohol and prescription drugs and about 7600 to aspirin and other OTC painkillers. Worldwide we can expect that the figures will be about 10 million for tobacco, 2.5 million each for others and about 200,000 for aspirin and OTC painkillers. There may be�1 million people in the world with fetal alcohol syndrome(severe�brain damage due to maternal drinking) and it is the leading cause of mental retardation in most countries. �There are also at least�15 million people�who have fetal alcohol effect(lesser degrees of brain damage) with about 200,000�born every year.�I suspect this is a gross underestimate.

�None of the psychedelics nor cannabis are known to produce fetal injury when taken in normal amounts.��All things considered, if�you calculated the lifetime risks of death or injury from taking ecstasy, it is probably�comparable to that of driving ten km and significantly less than that of putting on a pair of skis.

In addition, the young people who comprise the vast majority of the users are heavy risk takers, a very percentage of whom have personality disorders.� There are about 60 million schizophrenics and the same number of manic depressives in the world.� When you add the depressives, schizotypal disorders, anorexics, alcoholics etc it is clear that perhaps a billion people have major mental problems, nearly half of all those are in the prime drug taking ages.�In addition nearly all of us�have periodic mood swings, medical problems and personal crises.�

�Based on various data in this book and elsewhere, �it appears that about�20 million people will take�something like 200�million pills of ecstasy�each �year.� In 1998 there were about 9 deaths�POSSIBLY�connected with�ecstasy�in the USA. These seem to actually�be due to�drinking too much or too little water and likely to taking large amounts of other drugs or alcohol.'�Ecstasy deaths(like those for marijuana and other psychedelics)�are extremely rare and seldom if ever due to the direct toxicity--the psychedelics having some the widest margins between the effective and the toxic doses of any drugs in medicine.�

�The fact is there was enough data to prove the psychedelics were safe and therapeutically effective 25 years ago.� If they were available OTC or perhaps even on prescription with the same general indications as say,�antibiotics, the black market and�adulterated drugs would quickly fade away.

�It is not clear that anyone has ever had serious permanent mental problems due to taking ecstasy(though they often have serious permanent benefits) and its�potential as a therapeutic agent are enormous.�It has a long and remarkable history as a highly effective and safe therapeutic adjunct. �Nevertheless, as with many other psychedelic drugs, the federal government has chosen to ignore medical advice and legal opinion and classify it with heroin as a Schedule 1 drug with no recognized medical value and the governments of many other countries have followed along like trained dogs.�
This book aims to provide accurate information on all aspects of MDMA(ecstasy) and it accomplishes this quite well.�

�The authors mostly try very hard to be fair and balanced in their approaches and are mostly experts in the field.� They caution about the difficulty of applying the data on animals to humans but they often do not go far enough in emphasizing the probable irrelevance of the animal data to humans.� E.G., in the chapter on risks, not only do most of the animals get large amounts intravenously, but there are no good control data.� We need to see what happens with the same animals with the same routes and relative doses with a variety of commonly used medicines(eg, antidepressants, mood elevators, asthmatics, appetite depressants, cold medicines, OTC pain pills etc etc. Will they, as one suspects, show similar changes in their brain chemistry, memory, blood flow etc?� Nobody knows as the government sponsored studies almost never test them. �We can only guess from scattered data in other studies which often show the same kinds of changes.� Consequently, if we applied the same criteria used for Prozac, Elavil, aspirin etc �we would either have to outlaw nearly all the drugs in current medical use or legalize all the psychedelics. However the government has no interest in being rational, fair or even sane and certainly none in allowing us the freedoms supposedly guaranteed by the Consititution,�and the Bill of Rights.�

�Wantly badly to err on the side of caution, several of the authors repeatedly warn(eg, p111) of the possibility of subtle long term damage yet they seem unconcerned by some half century of massive long term use of antidepressants, amphetamines, etc to say nothing of alcohol, caffeine and nicotine.� And only one bothers to mention(p 139)�that a half century of studies on chronic users(often intravenous and multidrug abusers)�of the closely related amphetamine and methamphetamine have failed to show evidence of Parkinsonism. And let us keep in mind that about 99% of all the MDMA fans use it only a few times in their lives in low oral doses.� The same is true of most other psychedelics and so it seems likely that the only long term behavioural effects in the vast majority of users will be some increase in insight, less rigid personalities, broader interests in art, music, religion and a generally happier life.

�The young people who comprise the vast majority of the users are heavy risk takers, a very high percentage of whom have personality disorders.� There are about 60 million schizophrenics and the same number of manic depressives in the world.� When you add the depressives, schizotypal disorders, anorexics, alcholics etc it is clear that perhaps a billion people have major mental problems -�nearly half of all those are in the prime drug taking ages.�In addition nearly all of us�have periodic mood swings, medical problems and personal crises.��In addition as some of the authors note (and as Holland often interjects in her�editoral notes) the ecstasy users are usually taking other drugs before, during and after their ecstasy(and�marijuana and other psychedelic�experiences).� � These include, almost universally, alcohol, tobacco and�caffeine(which are almost always ignored) as well as cocaine, amphetamine and methamphetamine, ketamine, dextromethorphan, asthmatics, and a wide variety or uppers, downers and prescription mood altering agents including birth control pills and Viagra, to say nothing of the steroids now approaching universal use in professional athletes in all sports(no the new ones�cannot generally be detected).� Yet as Holland�and others note, these other drugs are�usually not�mentioned and�a really good drug screen on the users appearing in clinics or used in studies is seldom done.� The point of all this is that the claim that ecstasy is�dangerous is not correct(and other psychedelics are mostly the same).� It's probable that skiing kills and injures more people in one season(most in car accidents!) or tobacco or alcohol in one day, than all psychedelics�combined have done since the beginning of recorded history.� Thus the demonizing of them does not correspond with reality.� In fact since more than 99% of all media on MDMA is negative it would be reasonable and desireable to remove all the comments on possible negative effects from this book and publish it as MDMA: miracle�medicine for the 21st century!�

�Billions of dollars have been spent on studies �nd programs aimed at showing that psychedelics are bad and almost nothing on their many positive effects. In fact most of the world has(naturally) followed the poorly educated, deeply repressed, conservative Christians who control the US Govt. in outlawing, for over 30 years, any medical use and any research that might show benefits!� The vast amount of practical experience with their benefits cannot even be published and the tens(maybe hundreds) of millions who have had major positive experiences cannot talk about them.� Its clear as day that the only serious problem with ecstasy is that it is new and it triggers the control and maybe the contamination templates in the monkey mind.�

�The evidence presented here shows that MDMA is very safe, rarely illusionogenic(though most authors follow the common practice of calling visual effects hallucinations, which they defintely are not). �Hallucinations-eg, seeing and hearing persons who are not there- are characteristic of schizophrenia, toxic psychoses, belladonoids(eg datura),�and dissociative anesthethics(PCP, ketamine).� They are so rare with psychedelics that one suspects that nearly all such cases are due to preexisting psychosis.� MDMA�probably belongs(with a variety of other drugs invented by Shulgin) in a new class called entactogens.� These are�unique in that in addition to catalyzing positive emotions and bonding, they are rapidly acting, nonsedating anxiolytics(decrease anxiety), anaesthetics(pain killers) and�antidepressants(which take days or weeks to act in comparison with minutes for MDMA!)�with remarkably few and mild side effects(in dramatic contrast with�nearly all�medical drugs which�have severe side effects�that are often fatal).

�There is along chapter devoted to the toxicity data on rats and monkeys usually dosed intravenously and chronically with huge amounts and to reports on chronic, high dose often IV multiple drug abusers, probably with a high incidence of preexisting mental adn physical problems.� Only Holland's desire for completeness justifies the inclusion of such data in this book.� It has about as much relevance to the occasional oral use by the vast majority of MDMA users as the study of chronic alcoholics has to the description of a dinner party where�2 people consume a bottle of wine.�

�Jansen(p 87,89) is afraid of this self medication at home and expecially at raves(massive all night music events)without a therapist but probably over 100 million people in the last 40 years have taken some 2 billion trips with LSD, MDMA, MDA, mescaline, peyote, amanita, psilocybin mushrooms, ketamine and many other psychedelics with amazingly little evidence of negative effects. And of course, syrian rue, amanita muscaria, peyote and other cacti, pitruri, datura, ayahuasca and countless other plants have been consumed in hundreds of societies for thousands and likely for tens of thousands of years, giving rise to much of our art, music and religion, with hardly a trace of tradition regarding bad effects, which people were usually quick to notice and avoid.� And, as�Jansen(the author of an excellent recent book on ketamine)notes, nobody writes up, or sends to the media, reports of positive effects.�

�One way to look at the really big picture is to call on our modern knowledge of cognitive and evolutionary psychology which tells us that the foundations of�human behavior�are�the result of the mechanical, unconscious functioning of the inference engines or templates that were evolved hundreds of thousands of years ago(or millions or tens or hundreds of millions depending on one's point of view) to enable small bands of primates to survive long enough to reproduce.� These templates take in all the info from the eyes, ears, etc. and memory and produce feelings or intuitions about how one should behave to optimize survival.� However templates for control, predator avoidance, contamination, etc which were so rational in a small group on the African savanna(or in the trees a few million years earlier) are totally irrational and and even suicidal now.� Relentlessly, and in agonizing slow motion, 6 billion people are following the dictates of their templates while the biosphere and what passes for civilization collapses around them. The devious, power mad, repressed and unconscious persons who gravitate to positions of power in government, military, religion, industry and academia are orchestrating the end of the world while their like-minded constituents cheer wildly.� It is these people and not the psychedelic users who are the criminals.

�Ecstasy and other psychedelics, preferably combined with various kinds of meditation and other physical and mental�therapies have a major potential to help people to break free from the automatisms that have guided behavior for millions of years.�Billions of people need this�medicine�to avoid a lifetime of suffering and unhappiness and often, suicide.��Let us hope that�it holds the answer as there does not seem to be any other and let us hurry--time is running out.�

ýOneýshould start byýputting things in perspective. The following background is necessary not only for all studies of psychoactive drugs, but for all studies of human behavior.
ýThere were about 400,000 USA deaths due to tobacco, 100,000 each to alcohol and prescription drugs and about 7600 to aspirin and other OTC painkillers. Worldwide we can expect that the figures will be about 10 million for tobacco, 2.5 million each for others and about 200,000 for aspirin and OTC painkillers. There may beý1 million people in the world with fetal alcohol syndrome(severeýbrain damage due to maternal drinking) and it is the leading cause of mental retardation in most countries. ýThere are also at leastý15 million peopleýwho have fetal alcohol effect(lesser degrees of brain damage) with about 200,000ýborn every year.ýI suspect this is a gross underestimate.

ýNone of the psychedelics nor cannabis are known to produce fetal injury when taken in normal amounts.ýýAll things considered, ifýyou calculated the lifetime risks of death or injury from taking ecstasy, it is probablyýcomparable to that of driving ten km and significantly less than that of putting on a pair of skis.

In addition, the young people who comprise the vast majority of the users are heavy risk takers, a very percentage of whom have personality disorders.ý There are about 60 million schizophrenics and the same number of manic depressives in the world.ý When you add the depressives, schizotypal disorders, anorexics, alcoholics etc it is clear that perhaps a billion people have major mental problems, nearly half of all those are in the prime drug taking ages.ýIn addition nearly all of usýhave periodic mood swings, medical problems and personal crises.ý

ýBased on various data in this book and elsewhere, ýit appears that aboutý20 million people will takeýsomething like 200ýmillion pills of ecstasyýeach ýyear.ý In 1998 there were about 9 deathsýPOSSIBLYýconnected withýecstasyýin the USA. These seem to actuallyýbe due toýdrinking too much or too little water and likely to taking large amounts of other drugs or alcohol.'ýEcstasy deaths(like those for marijuana and other psychedelics)ýare extremely rare and seldom if ever due to the direct toxicity--the psychedelics having some the widest margins between the effective and the toxic doses of any drugs in medicine.ý

ýThe fact is there was enough data to prove the psychedelics were safe and therapeutically effective 25 years ago.ý If they were available OTC or perhaps even on prescription with the same general indications as say,ýantibiotics, the black market andýadulterated drugs would quickly fade away.

ýIt is not clear that anyone has ever had serious permanent mental problems due to taking ecstasy(though they often have serious permanent benefits) and itsýpotential as a therapeutic agent are enormous.ýIt has a long and remarkable history as a highly effective and safe therapeutic adjunct. ýNevertheless, as with many other psychedelic drugs, the federal government has chosen to ignore medical advice and legal opinion and classify it with heroin as a Schedule 1 drug with no recognized medical value and the governments of many other countries have followed along like trained dogs.ý
This book aims to provide accurate information on all aspects of MDMA(ecstasy) and it accomplishes this quite well.ý

ýThe authors mostly try very hard to be fair and balanced in their approaches and are mostly experts in the field.ý They caution about the difficulty of applying the data on animals to humans but they often do not go far enough in emphasizing the probable irrelevance of the animal data to humans.ý E.G., in the chapter on risks, not only do most of the animals get large amounts intravenously, but there are no good control data.ý We need to see what happens with the same animals with the same routes and relative doses with a variety of commonly used medicines(eg, antidepressants, mood elevators, asthmatics, appetite depressants, cold medicines, OTC pain pills etc etc. Will they, as one suspects, show similar changes in their brain chemistry, memory, blood flow etc?ý Nobody knows as the government sponsored studies almost never test them. ýWe can only guess from scattered data in other studies which often show the same kinds of changes.ý Consequently, if we applied the same criteria used for Prozac, Elavil, aspirin etc ýwe would either have to outlaw nearly all the drugs in current medical use or legalize all the psychedelics. However the government has no interest in being rational, fair or even sane and certainly none in allowing us the freedoms supposedly guaranteed by the Consititution,ýand the Bill of Rights.ý

ýWantly badly to err on the side of caution, several of the authors repeatedly warn(eg, p111) of the possibility of subtle long term damage yet they seem unconcerned by some half century of massive long term use of antidepressants, amphetamines, etc to say nothing of alcohol, caffeine and nicotine.ý And only one bothers to mention(p 139)ýthat a half century of studies on chronic users(often intravenous and multidrug abusers)ýof the closely related amphetamine and methamphetamine have failed to show evidence of Parkinsonism. And let us keep in mind that about 99% of all the MDMA fans use it only a few times in their lives in low oral doses.ý The same is true of most other psychedelics and so it seems likely that the only long term behavioural effects in the vast majority of users will be some increase in insight, less rigid personalities, broader interests in art, music, religion and a generally happier life.

ýThe young people who comprise the vast majority of the users are heavy risk takers, a very high percentage of whom have personality disorders.ý There are about 60 million schizophrenics and the same number of manic depressives in the world.ý When you add the depressives, schizotypal disorders, anorexics, alcholics etc it is clear that perhaps a billion people have major mental problems -ýnearly half of all those are in the prime drug taking ages.ýIn addition nearly all of usýhave periodic mood swings, medical problems and personal crises.ýýIn addition as some of the authors note (and as Holland often interjects in herýeditoral notes) the ecstasy users are usually taking other drugs before, during and after their ecstasy(andýmarijuana and other psychedelicýexperiences).ý ý These include, almost universally, alcohol, tobacco andýcaffeine(which are almost always ignored) as well as cocaine, amphetamine and methamphetamine, ketamine, dextromethorphan, asthmatics, and a wide variety or uppers, downers and prescription mood altering agents including birth control pills and Viagra, to say nothing of the steroids now approaching universal use in professional athletes in all sports(no the new onesýcannot generally be detected).ý Yet as Hollandýand others note, these other drugs areýusually notýmentioned andýa really good drug screen on the users appearing in clinics or used in studies is seldom done.ý The point of all this is that the claim that ecstasy isýdangerous is not correct(and other psychedelics are mostly the same).ý It's probable that skiing kills and injures more people in one season(most in car accidents!) or tobacco or alcohol in one day, than all psychedelicsýcombined have done since the beginning of recorded history.ý Thus the demonizing of them does not correspond with reality.ý In fact since more than 99% of all media on MDMA is negative it would be reasonable and desireable to remove all the comments on possible negative effects from this book and publish it as MDMA: miracleýmedicine for the 21st century!ý

ýBillions of dollars have been spent on studies ýnd programs aimed at showing that psychedelics are bad and almost nothing on their many positive effects. In fact most of the world has(naturally) followed the poorly educated, deeply repressed, conservative Christians who control the US Govt. in outlawing, for over 30 years, any medical use and any research that might show benefits!ý The vast amount of practical experience with their benefits cannot even be published and the tens(maybe hundreds) of millions who have had major positive experiences cannot talk about them.ý Its clear as day that the only serious problem with ecstasy is that it is new and it triggers the control and maybe the contamination templates in the monkey mind.ý

ýThe evidence presented here shows that MDMA is very safe, rarely illusionogenic(though most authors follow the common practice of calling visual effects hallucinations, which they defintely are not). ýHallucinations-eg, seeing and hearing persons who are not there- are characteristic of schizophrenia, toxic psychoses, belladonoids(eg datura),ýand dissociative anesthethics(PCP, ketamine).ý They are so rare with psychedelics that one suspects that nearly all such cases are due to preexisting psychosis.ý MDMAýprobably belongs(with a variety of other drugs invented by Shulgin) in a new class called entactogens.ý These areýunique in that in addition to catalyzing positive emotions and bonding, they are rapidly acting, nonsedating anxiolytics(decrease anxiety), anaesthetics(pain killers) andýantidepressants(which take days or weeks to act in comparison with minutes for MDMA!)ýwith remarkably few and mild side effects(in dramatic contrast withýnearly allýmedical drugs whichýhave severe side effectsýthat are often fatal).

ýThere is along chapter devoted to the toxicity data on rats and monkeys usually dosed intravenously and chronically with huge amounts and to reports on chronic, high dose often IV multiple drug abusers, probably with a high incidence of preexisting mental adn physical problems.ý Only Holland's desire for completeness justifies the inclusion of such data in this book.ý It has about as much relevance to the occasional oral use by the vast majority of MDMA users as the study of chronic alcoholics has to the description of a dinner party whereý2 people consume a bottle of wine.ý

ýJansen(p 87,89) is afraid of this self medication at home and expecially at raves(massive all night music events)without a therapist but probably over 100 million people in the last 40 years have taken some 2 billion trips with LSD, MDMA, MDA, mescaline, peyote, amanita, psilocybin mushrooms, ketamine and many other psychedelics with amazingly little evidence of negative effects. And of course, syrian rue, amanita muscaria, peyote and other cacti, pitruri, datura, ayahuasca and countless other plants have been consumed in hundreds of societies for thousands and likely for tens of thousands of years, giving rise to much of our art, music and religion, with hardly a trace of tradition regarding bad effects, which people were usually quick to notice and avoid.ý And, asýJansen(the author of an excellent recent book on ketamine)notes, nobody writes up, or sends to the media, reports of positive effects.ý

ýOne way to look at the really big picture is to call on our modern knowledge of cognitive and evolutionary psychology which tells us that the foundations ofýhuman behaviorýareýthe result of the mechanical, unconscious functioning of the inference engines or templates that were evolved hundreds of thousands of years ago(or millions or tens or hundreds of millions depending on one's point of view) to enable small bands of primates to survive long enough to reproduce.ý These templates take in all the info from the eyes, ears, etc. and memory and produce feelings or intuitions about how one should behave to optimize survival.ý However templates for control, predator avoidance, contamination, etc which were so rational in a small group on the African savanna(or in the trees a few million years earlier) are totally irrational and and even suicidal now.ý Relentlessly, and in agonizing slow motion, 6 billion people are following the dictates of their templates while the biosphere and what passes for civilization collapses around them. The devious, power mad, repressed and unconscious persons who gravitate to positions of power in government, military, religion, industry and academia are orchestrating the end of the world while their like-minded constituents cheer wildly.ý It is these people and not the psychedelic users who are the criminals.

ýEcstasy and other psychedelics, preferably combined with various kinds of meditation and other physical and mentalýtherapies have a major potential to help people to break free from the automatisms that have guided behavior for millions of years.ýBillions of people need thisýmedicineýto avoid a lifetime of suffering and unhappiness and often, suicide.ýýLet us hope thatýit holds the answer as there does not seem to be any other and let us hurry--time is running out.ý

I agree with the other user who put a 5 star rating to counter the blatant "I'm giving this 1 star (twice) because it doesn't absolutely condemn everyone who even thinks about using drugs" review. If, as other readers' comments imply, this includes some positive stuff about E then so be it. It's to be expected - I have used it a few times (not before some serious and surprising research into getting all the benefits at the lowest cost) and will use it again. I'd therefore encourage anyone interested in the topic to read up on it online or through books like these that are written by real experts rather than Government sources whose only interests are in scaremongering and getting people to use more destructive but legal drugs like booze and cigs in order to rake in as much tax as possible. No I have not read this particular book but in reading other reviews you can tell who is talking crap and who has approached the topic with an open mind. 1 star protests really *!?! me off.

I'm just writing a positive review to offset the biassed idiot who probably didn;t read the book, and who wrote two 1-star reviews to bash it.

I'm just writing a positive review to offset the biassed idiot who probably didn;t read the book, and who wrote two 1-star reviews to bash it.

This book is excellent.

It is very well written and can be easily read by lay persons as well as being a great source of information for health professionals (researchers, psychologists, psychiatrists,and all MDs.)

All of the important people in the field of MDMA research and history (Sasha and Ann Shulgin, Rick Doblin, among others) are either interviewed or have written chapters in the book.
The book is very informative and gives the extreme potential of this unique chemical. It is written by one of the most respected experts on MDMA.

This book is as objective as can be. Possible risks of MDMA use as well as the possible benefits are discussed in detail.

It is a must read for anyone interested in the topic of MDMA/ecstasy.

All royalties from the sale of this book will go toward funding clinical MDMA research.

This book is excellent.

It is very well written and can be easily read by lay persons as well as being a great source of information for health professionals (researchers, psychologists, psychiatrists,and all MDs.)

All of the important people in the field of MDMA research and history (Sasha and Ann Shulgin, Rick Doblin, among others) are either interviewed or have written chapters in the book.
The book is very informative and gives the extreme potential of this unique chemical. It is written by one of the most respected experts on MDMA.

This book is as objective as can be. Possible risks of MDMA use as well as the possible benefits are discussed in detail.

It is a must read for anyone interested in the topic of MDMA/ecstasy.

All royalties from the sale of this book will go toward funding clinical MDMA research.

This book is by far the best info/guide on MDMA. Julie Holland does an amazing job with going in-depth analysis over MDMA. I have heard others bashing her and saying that this book promotes MDMA use.. it does not. It simply states what it is all about and it actually lists everything that you could ever want to know about this popular drug. I sincerely hope that every MDMA user will read this book before getting into this.
Thanks Julie!

It is very suspicious that the two reviewers who gave this book 1 star wrote with almost identical sentence structure and using identical phrases within just 4 days of each other. There was obvious collusion and it raises questions about the validity of this kind of anonymous open review process.

This book deserves 5 stars. Holland did a good job and living up to the book's title "the complete guide." ... holland gets the 5 stars because she did what she set out to do.

Dr. Holland does a very solid job of editing this compendum of essays, studies and overviews of MDMA. I have not read another review that feels that this book is poorly written yet it receives 1 star ratings b/c it somehow doesn't demonize the use of ecstasy enough? Let's get real. Dr. Holland is in no way an advocate for the unregulated use of ecstasy but rather makes a very compelling argument that it should be studied in greater detail, including "gasp" possible clinical trials for treating certain psychiatric conditions. Let's not forget that the most popular illegal drug today, maurijuana, was only made illegal after intense pressure put on the FDR administration by the paper and tobacco lobbies. Despite the fact that hemp has none of the drugs pyschoactive ingredients and could be used to make paper at a lower cost and more environmentally friendly means than wood pulp it remains illegal in this country today.

A timely and fascinating treatment of issues relating to ecstasy usage, both recreational and as a tool for therapy. However, the book's "scientific" authorship are precisely what makes the book dangerous in that it seems to promote drug abuse as safe, although when read closely the data does not appear to support this conclusion so clearly. Perhaps the jury is still out on long-term adverse effects of MDMA. When the drug in question has potential to alter and damage neural structures of today's youth, perhaps a more cautious approach is in order. A great read, but the authors' presupposition of the drug's safety appears unfounded, even given information cited.

A provacative, thought-inspiring work which focuses on timely and important topics. However, the danger exists that this book in presenting itself as a "scientific" work will promote drug use. While many chapters were fascinating, the book's overall premise seems to be that moderate MDMA usage is without potential adverse effects. I found data supporting this premise to be largely lacking from this book. Maybe such data is not available, but if not, how can the authors' be so sure long-term, moderate usage of this substance is safe? Perhaps the jury is still out.

Psychiatrist and researcher Julie Holland M.D. has done a great job assembling this collection of essays on MDMA. With contributions from Andrew Weil, Ralph Metzner, Zalman Schacter, Rick Doblin, Douglas Rushkoff and many others, the book very honestly analyzes Ecstasy from many viewpoints: medical, psychotherapeutic, public health, criminal, social, and historical.

Holland and her contributors have created the best book on Ecstasy in print...it is destined to be considered a classic.